A xanthone with diverse biological activities
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Gentisein

Item No. 33877

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3,7-trihydroxy-9H-xanthen-9-one
CAS Number
529-49-7
Synonyms
  • NSC 329491
Molecular Formula
C13H8O5
Formula Weight
244.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 20 mg/ml
SMILES
O=C1C2=CC(O)=CC=C2OC3=CC(O)=CC(O)=C13
InChi Code
InChI=1S/C13H8O5/c14-6-1-2-10-8(3-6)13(17)12-9(16)4-7(15)5-11(12)18-10/h1-5,14-16H
InChi Key
JJUNZBRHHGLJQW-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $121

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    250 mg

    $255

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    500 mg

    $477

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    1 g

    $894

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    Cayman Chemical
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    Product Description

    Gentisein is a xanthone that has been found in H. annulatum and has diverse biological activities.1,2,3 It scavenges DPPH (Item No. 14805) radicals and inhibits the activity of α-glucosidase in cell-free assays (IC50s = 23.3 and 14.7 µM, respectively).1,2 Gentisein is cytotoxic against K562 chronic multiple leukemia cells, drug-sensitive HL-60 acute promyelocyte leukemia cells, and multidrug-resistant HL-60/DOX cells (IC50s = 102, 90.9, and 88.3 µM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhong, F.-F., Chen, Y., and Yang, G.-Z. Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Molecules 15(10), 7438-7449 (2008).

    2. Liu, Y., Zou, L., Ma, L., et al. Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors. Bioorg. Med. Chem. 14(16), 5683-5690 (2006).

    3. Biljali, S., Nedialkov, P., Zheleva-Dimitrova, D., et al. Cytotoxic effects and multidrug resistance modulation by five benzophenones and a xanthone Isolated from Hypericum annulatum Moris SUBSP. Annulatum. Biotechnol. Biotechnol. Equip. 27(1), 3561-3568 (2014).