A NSAID and COX-2 inhibitor
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GW 406381

Item No. 33895

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine
Synonyms
  • GW406381X
Molecular Formula
C21H19N3O3S
Formula Weight
393.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/ml, sonicated
SMILES
O=S(C1=CC=C(C2=C3C=CC=NN3N=C2C4=CC=C(C=C4)OCC)C=C1)(C)=O
InChi Code
InChI=1S/C21H19N3O3S/c1-3-27-17-10-6-16(7-11-17)21-20(19-5-4-14-22-24(19)23-21)15-8-12-18(13-9-15)28(2,25)26/h4-14H,3H2,1-2H3
InChi Key
NXMZBNYLCVTRGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

    Add

    5 mg

    $153

    Add

    10 mg

    $268

    Add

    25 mg

    $567

    Add
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    Product Description

    GW 406381 is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 3 nM).1 It is selective for COX-2 over COX-1 (IC50 = >84.2 µM). GW 406381 (5 mg/kg) reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beswick, P., Bingham, S., Bountra, C., et al. Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 14(21), 5445-5448 (2004).

    2. Zhao, F.-Y., Spanswick, D., Martindale, J.C., et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain 128(1-2), 78-87 (2007).