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Prohexadione is a plant growth regulator.1 It inhibits the gibberellin plant hormone biosynthesis enzyme 3β-hydroxylase when used at concentrations of 0.1, 1, and 10 mM. It reduces the shoot length of peanut plants when applied at 0.5, 1.5, and 4.5 kg/hectare. Prohexadione also inhibits jumonji domain-containing 2A (JMJD2A) demethylase when used at a concentration of 1 mM and induces the differentiation of mouse neurospheres into neurons at 1, 1.5, and 2 mM.2 Formulations containing prohexadione have been used as plant growth regulators in agriculture.
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1. Daminozide and prohexadione have similar modes of action as inhibitors of the late stages of gibberellin metabolism. Physiol. Plant. 101(2), 309-313 (1997).
2. Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics. Toxicol. Rep. 1, 1152-1161 (2014).