A bile acid
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Norursodeoxycholic Acid

Item No. 33925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,7β)-3,7-dihydroxy-24-norcholan-23-oic acid
CAS Number
99697-24-2
Synonyms
  • norUDCA
  • 24-Norursodeoxycholic Acid
  • Nourcholic Acid
Molecular Formula
C23H38O4
Formula Weight
378.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](CC(O)=O)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@@H]3O)C
InChi Code
InChI=1S/C23H38O4/c1-13(10-20(26)27)16-4-5-17-21-18(7-9-23(16,17)3)22(2)8-6-15(24)11-14(22)12-19(21)25/h13-19,21,24-25H,4-12H2,1-3H3,(H,26,27)/t13-,14+,15-,16-,17+,18+,19+,21+,22+,23-/m1/s1
InChi Key
QYYDXDSPYPOWRO-JHMCBHKWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Norursodeoxycholic acid (norUDCA) is a bile acid and the C23 homolog of UDCA (Item No. 15121).1,2 Unlike UDCA, norUDCA does not undergo conjugation to taurine or glycine and is secreted in an unchanged form, as trihydroxy derivatives, or as sulfate or glucuronide conjugates. Dietary administration of norUDCA (0.5% w/w) decreases serum levels of alanine aminotransferase (ALT) and alkaline phosphatase, markers of cholestasis, periductal fibrosis, and hepatic hydroxyproline content in an Mdr2-/- mouse model of sclerosing cholangitis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fickert, P., Wagner, M., Marschall, H.-U., et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 130(2), 465-481 (2006).

    2. Hofmann, A.F., Zakko, S.F., Lira, M., et al. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology 42(6), 1391-1398 (2005).