An aldosterone synthase inhibitor
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Osilodrostat

Item No. 33928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile
CAS Number
928134-65-0
Synonyms
  • LCI699
Molecular Formula
C13H10FN3
Formula Weight
227.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
227 nm
SMILES
FC1=C(C=CC(C#N)=C1)[C@]2([H])N3C(CC2)=CN=C3
InChi Code
InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
InChi Key
USUZGMWDZDXMDG-CYBMUJFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $96

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    10 mg

    $160

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    25 mg

    $306

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    50 mg

    $561

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    Product Description

    Osilodrostat is an inhibitor of aldosterone synthase (IC50 = 0.7 nM for the recombinant human enzyme).1 It is selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM). Osilodrostat inhibits increases in plasma aldosterone levels induced by angiotensin II or adrenocorticotropic hormone (ACTH) in rats (ED50s = 0.6 and 1.1 mg/kg, respectively). It reduces mean arterial pressure and prolongs survival in rats expressing human renin and angiotensinogen, a double-transgenic model of angiotensin II-dependent hypertension, in a dose-dependent manner. Formulations containing osilodrostat have been used in the treatment of Cushing’s syndrome.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ménard, J., Rigel, D.F., Watson, C., et al. Aldosterone synthase inhibition: Cardiorenal protection in animal disease models and translation of hormonal effects to human subjects. J. Transl. Med. 12, 340 (2014).