A myeloperoxidase inhibitor
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AZD 5904

Item No. 33931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-6H-purin-6-one
CAS Number
618913-30-7
Molecular Formula
C10H12N4O2S
Formula Weight
252.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
234, 291 nm
SMILES
O=C(NC1=S)C(NC=N2)=C2N1C[C@H]3CCCO3
InChi Code
InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
InChi Key
RSPDBEVKURKEII-ZCFIWIBFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $236

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    AZD 5904 is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.2 µM in a cell-free assay).1 It enhances decreases in the mitochondrial membrane potential in, and the viability of, MOLM-14 acute myeloid leukemia (AML) cells when used in combination with cytarabine (Item No. 16069).2 AZD 5904 (75 µmol/kg) prevents high-fat diet-induced increases in microvascular blood flow and microvascular blood volume in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tidén, A.-K., Sjögren, T., Svensson, M., et al. 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. The Journal of Biological Chemisty 286(43), 37578-37589 (2011).

    2. Hosseini, M., Rezvani, H.R., Aroua, N., et al. Targeting myeloperoxidase disrupts mitochondrial redox balance and overcomes cytarabine resistance in human acute myeloid leukemia. Cancer Res. 79(20), 5191-5203 (2019).

    3. Chai, W., Aylor, K., Liu, Z., et al. Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. Am. J. Physiol. Endocrinol. Metab. 317(6), E1063-E1069 (2019).