An internal standard for the quantification of methazolamide
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Methazolamide-d6

Item No. 33933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide-d6
CAS Number
1795142-30-1
Molecular Formula
C5H2D6N4O3S2
Formula Weight
242.3
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C(/N=C1SC(S(N)(=O)=O)=NN\1C([2H])([2H])[2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4-/i1D3,2D3
InChi Key
FLOSMHQXBMRNHR-OXIQCEOHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $439

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    Product Description

    Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide (Item No. 23413) by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM).1 It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg.2 It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH.3 Formulations containing methazolamide have been used in the treatment of glaucoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
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