For immunochemical detection of IL-6
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Interleukin-6 Monoclonal Antibody (Clone 19)

Item No. 33947

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • B Cell Stimulatory Factor 2
  • BSF-2
  • CDF
  • CTL Differentiation Factor
  • HGF
  • HSF
  • Hybridoma Growth Factor
  • IFN-β-2
  • IL-6
  • Interferon β-2
Immunogen
Recombinant human IL-6 protein
Clone Designation
19
MW
24 kDa
Formulation (Request formulation change)
200 μl of protein A-purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Mouse
Isotype
IgG1
Applications
IHC, WB
Cross Reactivity
(+) Human IL-6
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $120

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    100 µl

    $181

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    200 µl

    $240

    Add
    Cayman Chemical
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    Product Description

    IL-6 is a cytokine with roles in both the initiation and resolution of inflammatory responses.1,2 IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.3 It also induces tumor growth and metastasis via activation of JAK/STAT signaling.4 Cayman's Interleukin-6 Monoclonal Antibody (Clone 19) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The predicted size of IL-6 is 24 kDa and this antibody recognizes IL-6 at an observed band size of 30 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Del Giudice, M., and Gangestad, S.W. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav. Immun. 70, 61-75 (2018).

    2. Rose-John, S. Interleukin-6 family cytokines. Cold Spring Harb. Perspect. Biol. 10(2), a028415 (2018).

    3. Schett, G. Physiological effects of modulating the interleukin-6 axis. Rheumatology (Oxford) 57(suppl_2), ii43-ii50 (2018).

    4. Lacina, L., Brábek, J., Král, V., et al. Interleukin-6: A molecule with complex biological impact in cancer. Histol. Histopathol. 34(2), 125-136 (2019).