A P2Y2 and P2Y4 receptor agonist
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Diquafosol (sodium salt)

Item No. 33971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine 5′-(pentahydrogen tetraphosphate), P′′′→5′-ester with uridine, tetrasodium salt
CAS Number
211427-08-6
Synonyms
  • INS365
  • KPY 998
Molecular Formula
C18H22N4O23P4 • 4Na
Formula Weight
878.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
263 nm
SMILES
O=P(OC[C@H]1O[C@@](N2C=CC(NC2=O)=O)([C@@H]([C@@H]1O)O)[H])([O-])OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@@](N4C(NC(C=C4)=O)=O)([H])O3)([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C18H26N4O23P4.4Na/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30;;;;/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30);;;;/q;4*+1/p-4/t7-,8-,11-,12-,13-,14-,15-,16-;;;;/m1..../s1
InChi Key
OWTGMPPCCUSXIP-FNXFGIETSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $173

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    25 mg

    $315

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    50 mg

    $514

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    Product Description

    Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays).1 It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease.2 Formulations containing diquafosol have been used in the treatment of dry eye disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pendergast, W., Yerxa, B.R., Douglass, J.G., III, et al. Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11(2), 157-160 (2001).

    2. Fujihara, T., Murakami, T., Nagano, T., et al. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J. Ocul. Pharmacol. Ther. 18(4), 363-370 (2002).