An internal standard for the quantification of drospirenone
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Drospirenone-13C3

Item No. 34008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-3',4,4a,4b,4',5,6,6a,7a,8,8a,8b,8c,8d,9,9a-hexadecahydro-5'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H)-dione-3',4',5'-13C3
Synonyms
  • 1,2-dihydro Spirorenone-13C3
  • ZK 30595-13C3
Molecular Formula
C21[13C]3H30O3
Formula Weight
369.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: soluble
SMILES
O=C1CC[C@@]2(C)C([C@@](C3)([H])[C@@]3([H])[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])[C@@](C6)([H])[C@@]6([H])[C@@]57[13CH2][13CH2][13C](O7)=O)=C1
InChi Code
InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1/i5+1,8+1,19+1
InChi Key
METQSPRSQINEEU-FYXUFONYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $219

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    5 mg

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    Product Description

    Drospirenone-13C3 is intended for use as an internal standard for the quantification of drospirenone (Item No. 23347) by GC- or LC-MS. Drospirenone is a synthetic progestogen.1 In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously.2 Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone and luteinizing hormone (LH) in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pollow, K., Juchem, M., Elger, W., et al. Dihydrospirorenone (ZK30595): A novel synthetic progestagen - characterization of binding to different receptor proteins. Contraception 46(6), 561-574 (1992).

    2. Muhn, P., Fuhrmann, U., Fritzemeier, K.-H., et al. Drospirenone: A novel progestogen with antimineralocorticoid and antiandrogenic activity. Ann. N. Y. Acad. Sci. 761(1), 311-335 (1995).

    3. Apter, D., Zimmerman, Y., Beekman, L., et al. Bleeding pattern and cycle control with estetrol-containing combined oral contraceptives: Results from a phase II, randomised, dose-finding study (FIESTA). Contraception 94(4), 366-373 (2016).