An internal standard for the quantification of pranoprofen
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Unlabeled Version(s)
17875Pranoprofen
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Pranoprofen-13C-d3

Item No. 34009

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-13C-d3-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
Synonyms
  • Pyranoprofen-13C-d3
  • Y 8004-13C-d3
Molecular Formula
C14[13C]H10D3NO3
Formula Weight
259.3
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
SMILES
O=C(C([13C]([2H])([2H])[2H])C1=CC=C2OC3=NC=CC=C3CC2=C1)O
InChi Code
InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)/i1+1D3
InChi Key
TVQZAMVBTVNYLA-KQORAOOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $124

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    1 mg

    $234

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    5 mg

    $979

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    Product Description

    Pranoprofen-13C-d3 is intended for use as an internal standard for the quantification of pranoprofen (Item No. 17875) by GC- or LC-MS. Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM).1,2 It decreases B. pertussis-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated rat peritoneal leukocytes (IC50 = 0.39 µM).2 Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, M., Gureeye, A., Cissé, Y., et al. The therapeutic effects and possible mechanism of pranoprofen in mouse model of corneal alkali burns. J. Ophthalmol. 7485912 (2020).

    2. Naka, Y., Yamada, I., Ochi, H., et al. Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agents. Bioorg. Med. Chem. Lett. 5(9), 959-962 (1995).