A STAT3 inhibitor
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CAY10784

Item No. 34020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide
CAS Number
1245814-52-1
Molecular Formula
C11H6F3N3O3S
Formula Weight
317.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
232, 342 nm
SMILES
O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC=C([N+]([O-])=O)S2
InChi Code
InChI=1S/C11H6F3N3O3S/c12-11(13,14)7-3-1-6(2-4-7)9(18)16-10-15-5-8(21-10)17(19)20/h1-5H,(H,15,16,18)
InChi Key
HKCGJKNZQDBZFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $481

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    25 mg

    $1,053

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    Cayman Chemical
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    Product Description

    CAY10784 is a STAT3 inhibitor (IC50 = 0.74 µM in a reporter assay) and a derivative of WP1066 (Item No. 14736).1 It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 µM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lü, Z., Li, X., Li, K., et al. Structure–activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitors. ACS Med. Chem. Lett. (2021).

    2. Ballard, T.E., Wang, X., Olekhnovich, I., et al. Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activity. ChemMedChem 6(2), 362-377 (2011).