A terpenoid with diverse biological activities
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Alisol A

Item No. 34050

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8α,9β,14β)-11β,23S,24R,25-tetrahydroxy-dammar-13(17)-en-3-one
CAS Number
19885-10-0
Molecular Formula
C30H50O5
Formula Weight
490.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
C[C@@]12[C@]([C@H](CC3=C([C@H](C)C[C@H](O)[C@@H](O)C(C)(O)C)CC[C@@]32C)O)([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC1)C
InChi Code
InChI=1S/C30H50O5/c1-17(15-21(32)25(34)27(4,5)35)18-9-13-29(7)19(18)16-20(31)24-28(6)12-11-23(33)26(2,3)22(28)10-14-30(24,29)8/h17,20-22,24-25,31-32,34-35H,9-16H2,1-8H3/t17-,20+,21+,22+,24+,25-,28+,29+,30+/m1/s1
InChi Key
HNOSJVWYGXOFRP-UNPOXIGHSA-N
Origin
Plant/Alisma orientalis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $134

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    5 mg

    $333

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    10 mg

    $597

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    Product Description

    Alisol A is a terpenoid that has been found in A. orientale and has diverse biological activities.1,2,3,4 It inhibits the secretion of hepatitis B virus (HBV) surface antigen in HBV-infected 2.2.15 cells (IC50 = 39 µM).2 Alisol A (20 and 40 µM) induces cell cycle arrest at the G0/G1 phase and autophagy in MDA-MB-231 human breast cancer cells.3 It reduces hepatic steatosis and increases in plasma triglyceride, total cholesterol, LDL-C, and HDL-C levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 100 mg/kg per day.4 Alisol A decreases blood glucose and insulin levels in intraperitoneal glucose and insulin tolerance tests, respectively, in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuda, H., Tomohiro, N., Yoshikawa, M., et al. Studies on Alismatis Rhizoma. II. Anti-complementary activities of methanol extract and terpene components from Alismatis Rhizoma (dried rhizome of Alisma orientale). Biol. Pharm. Bull. 21(12), 1317-1321 (1998).

    2. Zhang, Q., Jiang, Z.-Y., Luo, J., et al. Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors. Bioorg. Med. Chem. Lett. 18(16), 4647-4650 (2008).

    3. Lou, C., Xu, X., Chen, Y., et al. Alisol A suppresses proliferation, migration, and invasion in human breast cancer MDA-MB-231 cells. Molcecules 24(20), 3651 (2019).

    4. Ho, C., Gao, Y., Zheng, D., et al. Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. J. Cell Mol. Med. 23(8), 5108-5118 (2019).