A synthetic peptide fragment of galanin and an agonist of the GAL2 receptor
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Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 34065

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucinamide, trifluoroacetate salt
Synonyms
  • AR-M1896
  • Gal(2-11)-NH2
  • WTLNSAGYLL-NH2
Molecular Formula
C54H81N13O14 • XCF3COOH
Formula Weight
1136.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/ml
SMILES
N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)CC(C=C1)=CC=C1O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C54H81N13O14.C2HF3O2/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36;3-2(4,5)1(6)7/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75);(H,6,7)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-;/m0./s1
InChi Key
ILTGGRBAWMAFAK-DQGGFSSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $95

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    1 mg

    $168

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    5 mg

    $739

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    10 mg

    $1,290

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    Product Description

    Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay).1 It selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor).1,2 Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3 It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H.-X., Brumovsky, P., Schmidt, R., et al. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors. Proc. Natl. Acad. Sci. USA 98(17), 9960-9964 (2001).

    2. Lu, X., Lundström, L., and Bartfai, T. Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypes. Neuropeptides 39(3), 165-167 (2005).

    3. Kuteeva, E., Wardi, T., Lundström, L., et al. Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level. Neuropsychopharmacology 33(11), 2573-2585 (2008).