An SPHK1 activator
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K6PC-5

Item No. 34070

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo-decanamide
CAS Number
756875-51-1
Molecular Formula
C19H37NO4
Formula Weight
343.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
O=C(C(CCCCCC)C(CCCCCCC)=O)NC(CO)CO
InChi Code
InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24)
InChi Key
CGYVFCHCRBGGJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $451

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    Product Description

    K6PC-5 is a sphingosine kinase 1 (SPHK1) activator.1,2,3 It activates SPHK1 in F9-12 teratocarcinoma cell lysates and isolated murine blood in a concentration-dependent manner.1 K6PC-5 (25 and 50 µM) induces calcium oscillations in HaCaT keratinocytes. It inhibits cell death induced by oxygen-glucose deprivation/reoxygenation in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM.2 Topical administration of K6PC-5 (1%) increases stratum corneum integrity and corneodesmosome density in a mouse model of photoaging induced by long-term exposure to ultraviolet A (UVA) and UVB radiation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, J.H., Youm, J.K., Kwon, M.J., et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J. Invest. Dermatol. 128, 2166-2178 (2008).

    2. Liu, H., Zhang, Z., Xu, M., et al. K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation/re-oxygenation. Cell Physiol. Biochem. 51(4), 1908-1920 (2018).

    3. Park, H.-y., Youm, J.-K., Kwon, M.J., et al. K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. Exp. Dermatol. 17(1), 829-836 (2008).