A dynamin inhibitor
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Dynole 34-2

Item No. 34073

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
CAS Number
1128165-88-7
Molecular Formula
C25H36N4O
Formula Weight
408.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 50 mM
λmax
222, 274, 381 nm
SMILES
N#CC(C(NCCCCCCCC)=O)=CC1=CN(CCCN(C)C)C2=C1C=CC=C2
InChi Code
InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)
InChi Key
MYIMRONQBLZJFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $134

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    10 mg

    $242

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    Cayman Chemical
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    Product Description

    Dynole 34-2 is an inhibitor of dynamin (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively).1 It induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells when used at a concentration of 10 µM. Dynole 34-2 inhibits the proliferation of several cancer cell lines (GI50s = 5.8-15 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chircop, M., Pera, S., Mariana, A., et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol. Cancer Ther. 10(9), 1553-1562 (2011).

    Product Citations

    Chang, C.-C., Liu, Y.N., Xu, Z., et al. Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant. Front. Immunol. 16, 1664371 (2025).