A STING agonist
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diABZI STING Agonist 3

Item No. 34082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-(3-hydroxypropoxy)-1H-benzimidazole-5-carboxamide
CAS Number
2138299-29-1
Synonyms
  • CS-0029879
  • Diamidobenzimidazole Stimulator of Interferon Genes Agonist 3
  • Diamidobenzimidazole STING Agonist 3
  • diABZI STING Agonist 3
  • EX-A3217
  • HY-103665
  • Stimulator of Interferon Genes Agonist 3
  • STING Agonist 3
Molecular Formula
C37H42N12O6
Formula Weight
750.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 40 mg/ml, sonicated
SMILES
NC(C1=CC=C(C(N=C2NC(C3=CC(C)=NN3CC)=O)=C1)N2C/C=C/CN4C5=C(OCCCO)C=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O)=O
InChi Code
InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(32(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55-15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20,50H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8-7+
InChi Key
VHCDRDBBENBVEK-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    diABZI STING agonist 3 is an agonist of stimulator of interferon genes (STING).1 It binds to STING (IC50 = 0.32 nM in a FRET assay) and induces STING transcriptional activity in a reporter assay (EC50 = 31.62 nM). diABZI STING agonist 3 increases protein levels of Nod-like receptor protein 3 (NLRP3), IL-1β, and IL-18, but not cGAS or mtDNA, in macrophages.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Charnley, A.K., Darcy, M.G., Dodson, J.W., et al. Heterocyclic amides useful as protein modulators. (2017).

    2. Ning, L., Wei, W., Wenyang, J., et al. Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide. Clin. Transl. Med. 10(7), e228 (2020).