A STING agonist
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diABZI STING Agonist 2

Item No. 34088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide
CAS Number
2138300-40-8
Synonyms
  • CS-0087594
  • diABZI Stimulator of Interferon Genes Agonist 2
  • Diamidobenzimidazole STING Agonist-2
  • Diamidobenzimidazole Stimulator of Interferon Genes Agonist 2
  • HY-123943
  • STING Agonist diABZI Compound 2
  • STING Agonist (Compound 4)
  • STING Agonist 4
  • Stimulator of Interferon Genes Agonist (Compound 4)
  • Stimulator of Interferon Genes Agonist 4
Molecular Formula
C34H38N12O4
Formula Weight
678.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble
SMILES
NC(C1=CC=C(C(N=C2NC(C3=CC(C)=NN3CC)=O)=C1)N2CCCCN4C5=CC=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O)=O
InChi Code
InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23-17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)48)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)
InChi Key
ICZSAXDKFXTSGL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    diABZI STING agonist 2 is an agonist of stimulator of interferon genes (STING).1 It binds to STING with an apparent Kd value of 1.6 nM. It is selective for STING over the acute phase reactant orosomucoid 1 (ORM1; apparent Kd = 79 nM). diABZI STING agonist 2 increases phosphorylation of interferon regulatory factor 3 (IRF3) and STING in human peripheral blood mononuclear cells (PBMCs). It also induces secretion of IFN-β from PBMCs (EC50 = 3.1 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ramanjulu, J.M., Pesiridis, G.S., Yang, J., et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564(7736), 439-443 (2018).