A nitrofuran antiprotozoal and antibacterial agent
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Furazolidone

Item No. 34090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone
CAS Number
67-45-8
Synonyms
  • Furoxone
  • NSC 6469
  • Nifulidone
  • Nitrofurazolidone
  • Nitrofuroxon
  • Tikofuran
  • Trifurox
Molecular Formula
C8H7N3O5
Formula Weight
225.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
261, 355 nm
SMILES
O=C(OCC1)N1/N=C/C2=CC=C([N+]([O-])=O)O2
InChi Code
InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChi Key
PLHJDBGFXBMTGZ-WEVVVXLNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

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    Cayman Chemical
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    Product Description

    Furazolidone is a nitrofuran antiprotozoal agent and antibacterial agent.1,2,3 It is active against G. lamblia trophozoites (IC50 = 2.9 µM), as well as metronidazole-susceptible and -resistant T. vaginalis clinical isolates with minimum lethal concentration (MLC) values of less than 3.1 µg/ml.1,2 Furazolidone is also active against clinical isolates of Salmonella, Shigella, E. coli, and V. parahaemolyticus (MICs = ≤0.5-4 µg/ml).3 In vivo, furazolidone (50 mg/kg per day) reduces splenic and hepatic parasite burden in a golden hamster model of L. chagasi infection.4 Formulations containing furazolidone have been used in the treatment of bacterial and protozoal infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Campanati, L., and Monteiro-Leal, L.H. The effects of the antiprotozoal drugs metronidazole and furazolidone on trophozoites of Giardia lamblia (P1 strain). Parasitol Res. 88(1), 80-85 (2002).

    2. Narcisi, E.M., and Secor, W.E. In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Antimicrob. Agents and Chemother. 40(5), 1121-1125 (1996).

    3. Carlson, J.R., Thornton, S.A., Dupont, H.L., et al. Comparative in vitro activities of ten antimicrobial agents against bacterial enteropathogens. Antimicrob. Agents Chemother. 24(4), 509-513 (1983).

    4. Tempone, A.G., Mortara, R.A., de Andrade, H.F., Jr., et al. Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis. Int. J. Antimicrob. Agents 36(2), 159-163 (2010).