A guanidino compound with epileptogenic activity
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N-Amidino-L-aspartic Acid

Item No. 34092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(aminoiminomethyl)-L-aspartic acid
CAS Number
6133-30-8
Synonyms
  • Guanidinosuccinic Acid
  • NSC 49078
Molecular Formula
C5H9N3O4
Formula Weight
175.1
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
OC(C[C@H](NC(N)=N)C(O)=O)=O
InChi Code
InChI=1S/C5H9N3O4/c6-5(7)8-2(4(11)12)1-3(9)10/h2H,1H2,(H,9,10)(H,11,12)(H4,6,7,8)/t2-/m0/s1
InChi Key
VVHOUVWJCQOYGG-REOHCLBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $63

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    100 mg

    $118

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    250 mg

    $168

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    500 mg

    $303

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    Product Description

    N-Amidino-L-aspartic acid is a guanidino compound found in mammalian sera and the CNS.1 It induces whole-cell currents in rat hippocampal slices, an effect that can be reversed by the NMDA receptor antagonists D-AP5 (D-amino-5-phosphonovalerate; Item No. 14539) and ketamine. Intrahippocampal administration of N-amidino-L-aspartic acid induces status epilepticus and neuronal cell death in rats.2 Cerebrospinal fluid and serum levels of N-amidino-L-aspartic acid are increased in patients with renal failure.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D'Hooge, R., Raes, A., Lebrun, P., et al. N-methyl-D-aspartate receptor activation by guanidinosuccinate but not by methylguanidine: Behavioural and electrophysiological evidence. Neuropharmacology 35(4), 433-440 (1996).

    2. Pan, J.C., Pei, Y.Q., An, L., et al. Epileptiform activity and hippocampal damage produced by intrahippocampal injection of guanidinosuccinic acid in rat. Neurosci. Lett. 209(2), 121-124 (1996).