An intermediate in pyrimidine biosynthesis
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Ureidosuccinic Acid

Item No. 34126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(aminocarbonyl)-aspartic acid
CAS Number
923-37-5
Synonyms
  • N-Carbamoylaspartic Acid
  • N-Carbamoyl-DL-Aspartic Acid
  • NSC 120033
Molecular Formula
C5H8N2O5
Formula Weight
176.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(NC(CC(O)=O)C(O)=O)NO=C(NC(CC(O)=O)C(O)=O)N
InChi Code
InChI=1S/C5H8N2O5/c6-5(12)7-2(4(10)11)1-3(8)9/h2H,1H2,(H,8,9)(H,10,11)(H3,6,7,12)
InChi Key
HLKXYZVTANABHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $54

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    $238

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    10 g

    $418

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    Cayman Chemical
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    Product Description

    Ureidosuccinic acid is an intermediate in the de novo pyrimidine nucleotide biosynthesis pathway.1,2 It is formed from aspartate and carbamoyl phosphate via aspartate carbamoyltransferase.1 Ureidosuccinic acid (350 mg/kg) inhibits antitumor activity and toxicity induced by the aspartate carbamoyltransferase inhibitor N-phosphonacetyl-L-aspartate (PALA) in a murine Lewis lung carcinoma model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lowenstein, J.M., and Cohen, P.P. Studies on the biosynthesis of carbamylaspartic acid. The Journal of Biological Chemisty 220(1), 57-70 (1956).

    2. Anderson, E.P., Yen, C.Y., Mandel, H.G., et al. Ureidosuccinic acid as a precursor of nucleic acid pyrimidines in normal and tumor-bearing mice. The Journal of Biological Chemisty 213(2), 625-633 (1955).

    3. Johnson, R.K. Reversal of toxicity and antitumor activity of N-(phosphonacetyl)-L-aspartate by uridine or carbamyl-DL-aspartate in vivo. Biochem. Pharmacol. 26(1), 81-84 (1977).