A diterpenoid alkaloid with diverse biological activities
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Yunaconitine

Item No. 34127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,3α,6α,14α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14-tetrol, 8-acetate 14-(4-methoxybenzoate)
CAS Number
70578-24-4
Synonyms
  • Guayewuanine B
  • Yunnaconitine
Molecular Formula
C35H49NO11
Formula Weight
659.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
260 nm
SMILES
CO[C@@H](C[C@H]1O)C([C@@](C[C@@]23O)([H])[C@H](C2([H])OC(C(C=C4)=CC=C4OC)=O)[C@@]5(C[C@@H]3OC)OC(C)=O)(C(N6CC)C5[C@@H]7OC)[C@@]7([H])[C@@]1(C6)COC
InChi Code
InChI=1S/C35H49NO11/c1-8-36-16-32(17-41-3)22(38)13-23(43-5)35-21-14-33(40)24(44-6)15-34(47-18(2)37,26(29(35)36)27(45-7)28(32)35)25(21)30(33)46-31(39)19-9-11-20(42-4)12-10-19/h9-12,21-30,38,40H,8,13-17H2,1-7H3/t21-,22-,23+,24+,25-,26?,27+,28-,29?,30?,32+,33+,34-,35?/m1/s1
InChi Key
LLEMSCWAKNQHHA-TYPGWQRDSA-N
Origin
Plant/Aconitum carmichaelii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $165

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    25 mg

    $241

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    Product Description

    Yunaconitine is a diterpenoid alkaloid that has been found in A. vilmorinianum and has diverse biological activities.1 It is active against E. coli and B. subtilis (MICs = 32 and 8 µg/ml, respectively).1 Yunaconitine acts as a metal chelator, inhibiting ferrozine-Fe2+ complex formation with an IC50 value of 11.6 µg/ml. Yunaconitine has been found in the urine of patients with aconite poisoning.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, T.-P., Cai, L., Fang, H.-X., et al. Diterpenoid alkaloids from Aconitum vilmorinianum. Phytochemistry 116, 314-319 (2015).

    2. Lai, C.-K., Poon, W.-T., and Chan, Y.-W. Hidden aconite poisoning: Identification of yunaconitine and related aconitum alkaloids in urine by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 30(7), 426-433 (2006).