A positive allosteric modulator of mGluR5
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CDPPB

Item No. 34132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamide
CAS Number
781652-57-1
Molecular Formula
C23H16N4O
Formula Weight
364.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
264 nm
SMILES
O=C(C1=CC=CC(C#N)=C1)NC2=CC(C3=CC=CC=C3)=NN2C4=CC=CC=C4
InChi Code
InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
InChi Key
BKUIZWILNWHFHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $124

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    10 mg

    $176

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    25 mg

    $392

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    Product Description

    CDPPB is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5).1 It potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s = 10 and 20 nM for the human and rat receptor, respectively). CDPPB (30 mg/kg, s.c.) inhibits amphetamine-induced disruptions in prepulse inhibition (PPI) of the acoustic startle response in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lindsley, C.W., Wisnoski, D.D., Leister, W.H., et al. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J. Med. Chem. 47(24), 5825-5828 (2004).