A tyrosinase inhibitor
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3-O-ethyl-L-Ascorbic Acid

Item No. 34139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
86404-04-8
Synonyms
  • 3-EtAA
  • 3-O-Ethylascorbic Acid
Molecular Formula
C8H12O6
Formula Weight
204.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
246, 249 nm
SMILES
OC[C@@H]([C@]1([H])C(OCC)=C(C(O1)=O)O)O
InChi Code
InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1
InChi Key
ZGSCRDSBTNQPMS-UJURSFKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $44

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    10 g

    $80

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    25 g

    $173

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    50 g

    $258

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    Product Description

    3-O-ethyl-L-Ascorbic acid is an inhibitor of tyrosinase (IC50s = 16.65 and 29.69 mM for the human and mushroom enzymes, respectively).1,2 It also scavenges DPPH radicals (IC50 = 0.032 g/L).2 Formulations containing 3-O-ethyl-L-ascorbic acid have been used in cosmetic products as skin-lightening agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jeon, S.-H., Kim, K.-H., Koh, J.-U., et al. Inhibitory effects on L-dopa oxidation of tyrosinase by skin-whitening agents. Bull. Korean Chem. Soc. 26(7), 1135-1137 (2005).

    2. Liao, W.C., Huang, Y.-T., Lu, L.-P., et al. Antioxidant ability and stability studies of 3-O-ethyl ascorbic acid, a cosmetic tyrosinase inhibitor. J. Cosmet. Sci. 69(4), 233-243 (2018).