An HDAC1 and HDAC2 inhibitor
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BRD6929

Item No. 34149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-benzamide
CAS Number
849234-64-6
Synonyms
  • JQ12
Molecular Formula
C19H17N3O2S
Formula Weight
351.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
282 nm
SMILES
O=C(C1=CC=C(NC(C)=O)C=C1)NC2=C(N)C=CC(C3=CC=CS3)=C2
InChi Code
InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)
InChi Key
ABZSPJVXTTUFAA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $203

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    25 mg

    $451

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    Cayman Chemical
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    Product Description

    BRD6929 is a histone deacetylase 1 (HDAC1) and HDAC2 inhibitor (IC50s = 0.04 and 0.1 µM, respectively, for the recombinant human enzymes).1 It is selective for HDAC1 and HDAC2 over HDAC3 and HDAC8 (IC50s = >20 µM for both). BRD6929 inhibits proliferation of HCT116 human colon cancer cells but not non-cancerous human mammary epithelial cells (HMECs; IC50s = 4 and >50 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moradei, O.M., Mallais, T.C., Frechette, S., et al. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J. Med. Chem. 50(23), 5543-5546 (2007).