A fluoroquinolone antibiotic
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Zoliflodacin

Item No. 34203

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,4S,4aS)-11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]-Spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione
CAS Number
1620458-09-4
Synonyms
  • AZD0914
  • ETX0914
Molecular Formula
C22H22FN5O7
Formula Weight
487.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
250, 316 nm
SMILES
O=C1C2(C(NC(N1)=O)=O)[C@]3([H])N(C[C@H](O[C@H]3C)C)C4=C(F)C(ON=C5N6[C@H](COC6=O)C)=C5C=C4C2
InChi Code
InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
InChi Key
ZSWMIFNWDQEXDT-ZESJGQACSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Zoliflodacin is a fluoroquinolone antibiotic.1 It inhibits the supercoiling activity of bacterial DNA gyrase and topoisomerase IV DNA decatenation.2 It is active against 250 clinical isolates of N. gonorrhoeae, including extensively drug-resistant (XDR) and multidrug-resistant (MDR) strains, with MIC values ranging from 0.004 to 0.25 µg/ml.1 Zoliflodacin is also active against clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 0.03-0.5 mg/L), as well as 10 clinical isolates each of C. trachomatis and C. pneumoniae (MIC50s = 0.125 and 0.5 µg/ml, respectively).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobsson, S., Golparian, D., Alm, R.A., et al. High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea. Antimicrob. Agents Chemother. 58(9), 5585-5588 (2014).

    2. Biedenbach, D.J., Huband, M.D., Hackel, M., et al. In vitro activity of AZD0914, a novel bacterial DNA gyrase/topoisomerase IV inhibitor, against clinically relevant Gram-positive and fastidious Gram-negative pathogens. Antimicrob. Agents Chemother. 59(10), 6053-6063 (2015).

    3. Kohlhoff, S.A., Huband, M.D., and Hammerschlag, M.R. In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrob. Agents Chemother. 58(12), 7595-7596 (2014).