A metabolite of palonosetron
Related Products
Parent Compound(s)
16752Palonosetron (hydrochloride)
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Palonosetron N-oxide

Item No. 34212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS)-2,3,3a,4,5,6-hexahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-1H-benz[de]isoquinolin-1-one
CAS Number
813425-83-1
Molecular Formula
C19H24N2O2
Formula Weight
312.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 1 mg/ml
SMILES
[O-][N+]12C[C@@H](N3C[C@]4([H])C(C(C3=O)=CC=C5)=C5CCC4)C(CC2)CC1
InChi Code
InChI=1S/C19H24N2O2/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-20(19)17-12-21(23)9-7-13(17)8-10-21/h2,4,6,13,15,17H,1,3,5,7-12H2/t13?,15-,17-,21?/m1/s1
InChi Key
IQQIWUDYGYXXEA-BGAFOXLKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $107

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    5 mg

    $424

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    10 mg

    $740

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    25 mg

    $1,583

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    Product Description

    Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3 antagonist palonosetron (Item No. 16752).1 It is also a potential impurity in palonosetron preparations.2 Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stoltz, R.A., Cyong, J.-C., Shah, A., et al. Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects. J. Clin. Pharmacol. 44(5), 520-531 (2004).

    2. Vishnu Murthy, M., Srinivas, K., Kumar, R., et al. Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase. J. Pharm. Biomed. Anal. 56(2), 429-435 (2011).