A 5-LO inhibitor
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(±)5-HETE lactone

Item No. 34215

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrahydro-6-(1E,3Z,6Z,9Z)-1,3,6,9-pentadecatetraen-1-yl-2H-pyran-2-one
CAS Number
81517-87-5
Synonyms
  • (±)5-Hydroxyeicosatetraenoic Acid lactone
Molecular Formula
C20H30O2
Formula Weight
302.5
Purity
≥98%
Formulation
A 100 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 1 mg/ml
λmax
236 nm
SMILES
CCCCC/C=C\C/C=C\C/C=C\C=C/C1CCCC(=O)O1
InChi Code
InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(21)22-19/h6-7,9-10,12-14,16,19H,2-5,8,11,15,17-18H2,1H3/b7-6-,10-9-,13-12-,16-14+
InChi Key
QZMAEYDIHWEEAF-XTDASVJISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 µg

    $75

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    50 µg

    $134

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    100 µg

    $252

    Add
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    Product Description

    (±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-lipoxygenase from rat basophilic leukemia cells with an IC50 of 27 µM. The lactone is several times more potent than the linear (±)5-HETE.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kerdesky, F.A.J., Schmidt, S.P., Holms, J.H., et al. Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. J. Med. Chem. 30(7), 1177-1186 (1987).