A fluorescent probe for the detection of amyloids
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K114

Item No. 34218

Product Insert (PDF)
Technical Information
Formal Name
4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol
CAS Number
872201-12-2
Molecular Formula
C22H17BrO2
Formula Weight
393.3
Purity
≥98%
Emission
450 nm at pH 8.5; 520 nm at pH 10.5
Excitation
370 nm at pH 8.5; 420 nm at pH 10.5
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
OC(C=C1)=CC=C1/C=C/C2=C(C=C(C=C2)/C=C/C3=CC=C(C=C3)O)Br
InChi Code
InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+
InChi Key
OXPHQQMZTXMEGO-RJTULKDBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $152

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    50 mg

    $345

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    Product Description

    K114 is a fluorescent probe for the detection of amyloids.1 It displays pH-dependent excitation/emission maxima at 370/450 and 395/520 nm at pH 8.5 and 10.5, respectively, and demonstrates an increase in fluorescence intensity in the presence of amyloid-ß (1-40) (Aß40) fibrils. K114 also displays fiber-dependent excitation/emission maxima for silk moth (B. mori) silk, Chilean rose tarantula (G. rosea) web, and 5XFAD mouse brain amyloid fibers.2 It has been used to detect amyloid plaques in postmortem hippocampus from patients with Alzheimer's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. LeVine, H., III Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry 44(48), 15937-15943 (2005).

    2. Stepanchuk, A.A., Heyne, B., and Stys, P.K. Complex photophysical properties of K114 make for a versatile fluorescent probe for amyloid detection. ACS Chem. Neurosci. 12(7), 1273-1280 (2021).