A PDE10A inhibitor
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THPP-1

Item No. 34219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2-(6-chloro-3-pyridinyl)-7,8-dihydro-4-(2-methoxyethoxy)pyrido[4,3-d]pyrimidin-6(5H)-yl]imidazo[1,5-a]pyridin-1-yl-methanone
CAS Number
1257051-63-0
Molecular Formula
C23H21ClN6O3
Formula Weight
464.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
221, 287 nm
SMILES
O=C(N1CC2=C(OCCOC)N=C(C3=CN=C(Cl)C=C3)N=C2CC1)C4=C5C=CC=CN5C=N4
InChi Code
InChI=1S/C23H21ClN6O3/c1-32-10-11-33-22-16-13-29(23(31)20-18-4-2-3-8-30(18)14-26-20)9-7-17(16)27-21(28-22)15-5-6-19(24)25-12-15/h2-6,8,12,14H,7,9-11,13H2,1H3
InChi Key
JBHLOPKIPKTRSU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $306

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    10 mg

    $567

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    Product Description

    THPP-1 is an inhibitor of phosphodiesterase 10A (PDE10A; Ki = 1 nM).1 It is selective for PDE10A over PDE1A-9A and PDE11A (Kis = 44->50,000 nM for all). THPP-1 (3 mg/kg) decreases the number of avoidances in the conditioned avoidance response test in rats and reduces MK-801-induced increases in locomotor activity in mice.2 It improves novel object recognition in rats when administered at doses of 0.3 and 1 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raheem, I.T., Breslin, M.J., Fandozzi, C., et al. Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg. Med. Chem. Lett. 22(18), 5903-5908 (2012).

    2. Smith, S.M., Uslaner, J.M., Cox, C.D., et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology 64, 215-223 (2013).