An internal standard for the quantification of sarafloxacin
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Unlabeled Version(s)
20299Sarafloxacin (hydrochloride)
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Sarafloxacin-d8 (hydrochloride)

Item No. 34226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl-2,2,3,3,5,5,6,6-d8)-3-quinolinecarboxylic acid, monohydrochloride
CAS Number
2733145-07-6
Molecular Formula
C20H9D8F2N3O3 • HCl
Formula Weight
429.9
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1C2=CC(F)=C(N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])C=C2N(C4=CC=C(C=C4)F)C=C1C(O)=O.Cl
InChi Code
InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H/i5D2,6D2,7D2,8D2;
InChi Key
KNWODGJQLCISLC-CADLHFACSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Sarafloxacin-d8 is intended for use as an internal standard for the quantification of sarafloxacin (Item No. 20299) by GC- or LC-MS. Sarafloxacin is a fluoroquinolone antibiotic.1,2 It is active against various clinical isolates of bacteria, including Bacteroides, Fusobacterium, Eubacterium, Actinomyces, and Peptococcus (MICs = 0.5-2 µg/ml).1 Sarafloxacin inhibits P. aeruginosa DNA gyrase.3 It decreases air sac lesion severity in a chick model of E. coli-induced colisepticemia when administered at a dose of 8 mg/kg in the drinking water 24 hours per day for five days.2 Formulations containing sarafloxacin have previously been used in the treatment of bacterial infections in poultry.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bansal, M.B., and Thadepalli, H. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro. Antimicrob. Agents Chemother. 31(4), 619-621 (1987).

    2. Charleston, B., Gate, J.J., Aitken, I.A., et al. Comparison of the efficacies of three fluoroquinolone antimicrobial agents, given as continuous or pulsed-water medication, against Escherichia coli infection in chickens. Antimicrob. Agents Chemother. 42(1), 83-87 (1998).

    3. Moir, D.T., Di, M., Opperman, T., et al. A high-throughput, homogeneous, bioluminescent assay for Pseudomonas aeruginosa gyrase inhibitors and other DNA-damaging agents. J. Biomol. Screen. 12(6), 855-864 (2007).