A positive allosteric modulator of GPR68
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Ogerin

Item No. 34228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol
CAS Number
1309198-71-7
Synonyms
  • ZINC67740571
Molecular Formula
C17H17N5O
Formula Weight
307.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml
SMILES
OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1
InChi Code
InChI=1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
InChi Key
MDGIEDNDSFMSLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $116

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    10 mg

    $207

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    25 mg

    $469

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    Product Description

    Ogerin is a positive allosteric modulator of G protein-coupled receptor 68 (GPR68).1 It increases proton-induced cAMP production in HEK293T cells expressing the human receptor in a reporter assay. Ogerin inhibits proton-mediated calcium release in the same cells when used at a concentration of 10 µM. It impairs contextual, but not cued, fear conditioning in wild-type, but not Gpr68 knockout, mice when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, X.-P., Karpiak, J., Kroeze, W.K., et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527(7579), 477-483 (2015).