A P2X4 receptor antagonist
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BAY-1797

Item No. 34229

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-benzeneacetamide
CAS Number
2055602-83-8
Molecular Formula
C20H17ClN2O4S
Formula Weight
416.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O=C(CC1=CC=CC=C1)NC2=CC=C(C(S(=O)(N)=O)=C2)OC3=CC(Cl)=CC=C3
InChi Code
InChI=1S/C20H17ClN2O4S/c21-15-7-4-8-17(12-15)27-18-10-9-16(13-19(18)28(22,25)26)23-20(24)11-14-5-2-1-3-6-14/h1-10,12-13H,11H2,(H,23,24)(H2,22,25,26)
InChi Key
CSJYMAFXYMYNCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $127

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    10 mg

    $227

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    25 mg

    $499

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    Product Description

    BAY-1797 is an antagonist of the purinergic P2X4 receptor (IC50 = 0.211 µM for the human receptor).1 It is selective for P2X4 over P2X1, P2X3, and P2X7 receptors (IC50s = >50, 8.3, and 10.6 µM, respectively, for the human receptors), as well as a panel of G protein-coupled receptors (GPCRs), ion channels, kinases, and transporters at 10 µM. BAY-1797 (50 mg/kg) decreases intraplantar prostaglandin E2 (PGE2; Item No. 14010) levels and reduces non-evoked pain-related behavior in the dynamic weight bearing test in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Werner, S., Mesch, S., Hillig, R.C., et al. Discovery and characterization of the potent and selective P2X4 inhibitor N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of Its CYP3A4 induction profile. J. Med. Chem. 62(24), 11194-11217 (2019).