An inhibitor of MCT1
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BAY-8002

Item No. 34231

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-chloro-5-(phenylsulfonyl)benzoyl]amino]-benzoic acid
CAS Number
724440-27-1
Molecular Formula
C20H14ClNO5S
Formula Weight
415.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
214, 244 nm
SMILES
O=C(C1=C(NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O)C=CC=C1)O
InChi Code
InChI=1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25)
InChi Key
CLAUJSRBKSRTGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $161

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    25 mg

    $378

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    50 mg

    $553

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    Cayman Chemical
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    Product Description

    BAY-8002 is an inhibitor of monocarboxylate transporter 1 (MCT1; IC50 = 11.4 nM).1 It inhibits lactate uptake in DLD-1 cells expressing human MCT1 (IC50 = 85 nM) but not Evsa-T cells expressing human MCT4 (IC50 = >50 µM).1 It inhibits the proliferation of 24 cancer cell lines when used at a concentration of 10 µM. BAY-8002 (50 and 100 mg/kg) reduces intratumor lactate levels and tumor area in a Raji mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Quanz, M., Bender, E., Kopitz, C., et al. Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol. Cancer Ther. 17(11), 2285-2296 (2018).