An internal standard for the quantification of chlorzoxazone
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Unlabeled Version(s)
18869Chlorzoxazone
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Chlorzoxazone-d3

Item No. 34237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2(3H)-benzoxazolone-4,6,7-d3
CAS Number
1185173-60-7
Molecular Formula
C7HClD3NO2
Formula Weight
172.6
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
O=C1OC2=C([2H])C([2H])=C(Cl)C([2H])=C2N1
InChi Code
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)/i1D,2D,3D
InChi Key
TZFWDZFKRBELIQ-CBYSEHNBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $159

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    1 mg

    $302

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    5 mg

    $1,025

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    Product Description

    Chlorzoxazone-d3 is intended for use as an internal standard for the quantification of chlorzoxazone (Item No. 18869) by GC- or LC-MS. Chlorzoxazone is a centrally acting muscle relaxant and an activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively).1,2 In vivo, chlorzoxazone (10 mg/kg) decreases alcohol, but not water, intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol.3 Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pedarzani, P., and Stocker, M. Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell. Mol. Life Sci. 65(20), 3196-3217 (2008).

    2. Gao, Z., Todorov, B., Barrett, C.F., et al. Cerebellar ataxia by enhanced Cav2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1aS218L mutant mice. J. Neurosci. 32(44), 15533-15546 (2012).

    3. Hopf, F.W., Simms, J.A., Chang, S.-J., et al. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol. Psychiatry 69(7), 618-624 (2011).