An antimicrobial agent
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Octenidine (hydrochloride)

Item No. 34238

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanamine, dihydrochloride
CAS Number
70775-75-6
Synonyms
  • WIN 41,464-2
Molecular Formula
C36H62N4 • 2HCl
Formula Weight
623.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
214, 284 nm
SMILES
CCCCCCCC/N=C(C=C1)/C=CN1CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC.Cl.Cl
InChi Code
InChI=1S/C36H62N4.2ClH/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2;;/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1H
InChi Key
SMGTYJPMKXNQFY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Octenidine is an antimicrobial agent.1 It is active against a variety of bacteria, including methicillin-sensitive and -resistant S. aureus, vancomycin-resistant Enterococcus, E. faecalis, and S. pneumoniae (MICs = 1-32 mg/L), and the fungus C. albicans (MIC = 1 mg/L). Octenidine (2 mM) reduces methicillin- or vancomycin-resistant S. aureus biofilm formation.2 Topical application of octenidine (1%) reduces dental plaque accumulation in cynomolgus monkeys fed a high-sucrose diet.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koburger, T., Hübner, N.-O., Braun, M., et al. Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J. Antimicrob. Chemother. 65(8), 1712-1719 (2010).

    2. Amalaradjou, M.A.R., and Venkitanarayanan, K. Antibiofilm effect of octenidine hydrochloride on Staphylococcus aureus, MRSA and VRSA. Pathogens 3(2), 404-416 (2014).

    3. Emilson, C.G., Bowen, W.H., Robrish, S.A., et al. Effect of the antibacterial agents octenidine and chlorhexidine on the plaque flora in primates. Scand. J. Dent. Res. 89(5), 384-392 (1981).