A class Ic antiarrhythmic agent
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Heart
Arrhythmia

Pilsicainide (hydrochloride)

Item No. 34242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide, monohydrochloride
CAS Number
88069-49-2
Synonyms
  • SUN 1165
Molecular Formula
C17H24N2O • HCl
Formula Weight
308.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CC12N(CCC2)CCC1)NC3=C(C)C=CC=C3C.Cl
InChi Code
InChI=1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
InChi Key
NZOSVDHCTCLGEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $81

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    50 mg

    $115

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    100 mg

    $176

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    250 mg

    $395

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    Product Description

    Pilsicainide is a class Ic antiarrhythmic agent.1,2 It shortens action potential duration in canine Purkinje fibers, as well as increases the ratio of the effective refractory period to the duration of action potential in guinea pig atrial muscle strips, when used at a concentration of 10 µg/ml.1 Pilsicainide (3-10 mg/kg) restores sinus rhythm in a canine model of ventricular multifocal arrhythmias.2 It also suppresses arrhythmias induced by ouabain or halothane and epinephrine in dogs. Formulations containing pilsicainide have been used in the treatment of supraventricular and ventricular tachycardia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hattori, Y., Inomata, N., Aisaka, K., et al. Electrophysiological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidine-acetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent. J. Cardiovasc. Pharmacol. 8(5), 998-1002 (1986).

    2. Aisaka, K., Hidaka, T., Inomata, N., et al. N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): A new potent and long-acting antiarrhythmic agent. Arzneimittelforschung 35(8), 1239-1245 (1985).