An internal standard for the quantification of indapamide
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Indapamide-13C-d3

Item No. 34244

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-(2-methyl-13C-d3)-1H-indol-1-yl)-benzamide
CAS Number
2934053-07-1
Molecular Formula
C15[13C]H13D3ClN3O3S
Formula Weight
369.8
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
ClC1=C(S(N)(=O)=O)C=C(C(NN2C([13C]([2H])([2H])[2H])CC3=C2C=CC=C3)=O)C=C1
InChi Code
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)/i1+1D3
InChi Key
NDDAHWYSQHTHNT-KQORAOOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    5 mg

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    Product Description

    Indapamide-13C-d3 is intended for use as an internal standard for the quantification of indapamide by GC- or LC-MS. Indapamide is a carbonic anhydrase (CA) inhibitor (Kis = 0.23, 36, 10, and 13 nM for CAVII, CAIX, CAXII, and CAXIII, respectively).1 It is selective for these CAs over CAI-CAVI and CAXIV (Kis = 213->10,000 nM). Indapamide is a thiazide-like diuretic that reduces blood pressure in spontaneously hypertensive rats (SHRs).2 It also increases urinary and renovascular levels of 11,12-EET and 14,15-EET, decreases urinary levels of 11,12-DiHET and 14,15-DiHET, and reduces renal cortical malondialdehyde levels in SHRs. Formulations containing indapamide have been used in the treatment of hypertension, as well as salt and fluid retention associated with congestive heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Temperini, C., Cecchi, A., Scozzafava, A., et al. Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: When three water molecules and the keto-enol tautomerism make the difference. J. Med. Chem. 52(2), 322-328 (2019).

    2. Ma, F., Lin, F., Chen, C., et al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol. Pharmacol. 84(2), 286-295 (2013).