An internal standard for the quantification of moclobemide
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Moclobemide-d4

Item No. 34247

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-N-[2-(4-morpholinyl)ethyl]-benzamide-2,3,5,6-d4
CAS Number
2929883-33-8
Molecular Formula
C13H13D4ClN2O2
Formula Weight
272.8
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
ClC1=C([2H])C([2H])=C(C(NCCN2CCOCC2)=O)C([2H])=C1[2H]
InChi Code
InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)/i1D,2D,3D,4D
InChi Key
YHXISWVBGDMDLQ-RHQRLBAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $250

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    10 mg

    $470

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    25 mg

    $976

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    Product Description

    Moclobemide-d4 is intended for use as an internal standard for the quantification of moclobemide (Item No. 24361) by GC- or LC-MS. Moclobemide is a reversible inhibitor of monoamine oxidase A (MAO-A; Ki = 0.005 µM).1 It is selective for MAO-A over MAO-B (Ki = 1.08 µM). Chronic administration of moclobemide (15 mg/kg) decreases immobility in the forced swim test in rats.2 It increases time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity, when administered chronically at a dose of 20 mg/kg.3 Formulations containing moclobemide have been used in the treatment of major depressive disorder, bipolar disorder, and social anxiety.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jagrat, M., Behera, J., Yabanoglu, S., et al. Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies. Bioorg. Med. Chem. Lett. 21(14), 4296-4300 (2011).

    2. Cryan, J.F., Page, M.E., and Lucki, I. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacol. (Berl) 182(3), 335-344 (2005).

    3. Frank, M., and Braszko, J.J. Moclobemide enhances aversively motivated learning and memory in rats. Pol. J. Pharmacol. 51(6), 497-503 (1999).