An anxiolytic agent
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Alpidem

Item No. 34252

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
CAS Number
82626-01-5
Molecular Formula
C21H23Cl2N3O
Formula Weight
404.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
O=C(CC1=C(C2=CC=C(C=C2)Cl)N=C3C=CC(Cl)=CN31)N(CCC)CCC
InChi Code
InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
InChi Key
JRTIDHTUMYMPRU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $183

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    10 mg

    $329

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    25 mg

    $737

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    Product Description

    Alpidem is an anxiolytic agent.1 It selectively binds to α1β2γ2 subunit-containing GABAA receptors over α5β2γ2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and ≥10 µM, respectively, for the recombinant rat receptors).2 Alpidem also binds to the GABAA/benzodiazepine receptor complex and translocator protein 18 kDa (TSPO) with IC50 values of 0.028 and 0.0079 µM, respectively.3 It reduces marble burying in mice, indicating anxiolytic activity, with a minimum effective dose (MED) of 10 mg/kg.4 Unlike the benzodiazepine alprazolam, alpidem does not induce sedation in mice when administered at doses up to 2 mg/kg.5 Formulations containing alpidem have previously been used in the treatment of generalized anxiety disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Skolnick, P. Anxioselective anxiolytics: On a quest for the holy grail. Trends Pharamacol. Sci. 33(11), 611-620 (2012).

    2. Faure-Halley, C., Graham, D., Arbilla, S., et al. Expression and properties of recombinant α1β2γ2 and α5β2γ2 forms of the rat GABAA receptor. Eur. J. Pharmacol. 246(3), 283-287 (1993).

    3. Trapani, G., Franco, M.C., Ricciardi, L., et al. Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type. J. Med. Chem. 40(19), 3109-3118 (1997).

    4. Zivkovic, B., Morel, E., Joly, D., et al. Pharmacological and behavioral profile of alpidem as an anxiolytic. Pharmacopsychiatry 23(Suppl. 3), 108-113 (1990).

    5. Hascoët, M., and Bourin, M. Anticonflict effect of alpidem as compared with the benzodiazepine alprazolam in rats. Pharmacol. Biochem. Behav. 56(2), 317-324 (1997).