A COMT inhibitor
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Opicapone

Item No. 34253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-(2,5-dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
CAS Number
923287-50-7
Synonyms
  • BIA 9-1067
Molecular Formula
C15H10Cl2N4O6
Formula Weight
413.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
OC1=CC(C2=NC(C(C(C)=C3Cl)=C([N](=O)=C3C)Cl)=NO2)=CC([N+]([O-])=O)=C1O
InChi Code
InChI=1S/C15H10Cl2N4O6/c1-5-10(13(17)20(24)6(2)11(5)16)14-18-15(27-19-14)7-3-8(21(25)26)12(23)9(22)4-7/h3-4,22-23H,1-2H3
InChi Key
ASOADIZOVZTJSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $85

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    10 mg

    $113

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    25 mg

    $247

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    Product Description

    Opicapone is a peripherally selective inhibitor of catechol-O-methyltransferase (COMT).1 It inhibits COMT activity in rat liver, but not brain, homogenates (ED50 = 1.05 mg/kg). Opicapone (3 mg/kg) increases plasma levels of L-DOPA (Item No. 13248) and reduces plasma levels of 3-O-methyl-DOPA (3-OMD) when administered in combination with benserazide (Item No. 20298) and L-DOPA.2 Formulations containing opicapone have been used as adjuvants in the treatment of “off” episodes associated with Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiss, L.E., Ferriera, H.S., Torrão, L., et al. Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. J. Med. Chem. 53(8), 3396-3411 (2010).

    2. Bonifácio, M.J., Torrão, L., Loureiro, A.I., et al. Pharmacological profile of opicapone, a third generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. Br. J. Pharmacol. 172(7), 1739-1752 (2014).