A synthetic curcuminoid and activator of TFEB
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Curcumin analog C1

Item No. 34255

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E,4E)-1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one
CAS Number
39777-61-2
Synonyms
  • GO-Y019
  • TFEB Activator 1
Molecular Formula
C19H18O3
Formula Weight
294.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
366 nm
SMILES
COC1=C(/C=C/C(/C=C/C2=C(OC)C=CC=C2)=O)C=CC=C1
InChi Code
InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+
InChi Key
RCZMPCUUTSDNAJ-PHEQNACWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $107

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    10 mg

    $183

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    25 mg

    $304

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    Cayman Chemical
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    Product Description

    Curcumin analog C1 is a synthetic curcuminoid.1,2 It inhibits the proliferation of HCT116 colon cancer cells (GI50 = 4 µM).1 Curcumin analog C1 (1 µM) activates transcription factor EB (TFEB), inducing nuclear translocation in Neuro2a mouse neuroblastoma cells.2 It increases LC3-II levels and promotes autophagic flux in Neuro2a cells when used at a concentration of 1 µM. Curcumin analog C1 (10 and 25 mg/kg, p.o.) activates TFEB and increases autophagy and lysosome biogenesis in rat brain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamakoshi, H., Ohori, H., Kudo, C., et al. Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof. Bioorg. Med. Chem. 18(3), 1083-1092 (2010).

    2. Song, J.-X., Sun, Y.-R., Peluso, I., et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy 12(8), 1372-1389 (2016).