An inhibitor of protein aggregation
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Anle138b

Item No. 34259

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
CAS Number
882697-00-9
Molecular Formula
C16H11BrN2O2
Formula Weight
343.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
BrC1=CC=CC(C2=CC(C3=CC=C4C(OCO4)=C3)=NN2)=C1
InChi Code
InChI=1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)
InChi Key
RCQIIBJSUWYYFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $61

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    25 mg

    $120

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    50 mg

    $153

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    Product Description

    Anle138b is an inhibitor of protein aggregation.1 It inhibits α-synuclein oligomer formation and PrPSc prion propagation by 77 and 84%, respectively, when used at a concentration of 10 µM. Anle138b (1 mg/animal) inhibits brain accumulation of PrPSc in, and increases survival of, prion-infected mice. It reduces brain tau deposition and rescues glucose metabolic decline in a human tau transgenic mouse model of Alzheimer’s disease.2 Dietary administration of anle138b (0.6 and 2 g/kg chow) reduces the formation of α-synuclein oligomers and glial cytoplasmic inclusions, microglial activation, and dopaminergic neuron degradation, as well as preserves motor function, in a mouse model of multiple system atrophy (MSA).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wagner, J., Ryazanov, S., Leonov, A., et al. Anle138b: A novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease. Acta Neuropathol. 125(6), 795-813 (2013).

    2. Brendel, M., Deussing, M., Blume, T., et al. Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau. Alzheimers Res. Ther. 11(1), 67 (2019).

    3. Heras-Garvin, A., Weckbecker, D., Ryazanov, S., et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov. Disord. 34(2), 255-263 (2019).