A 1,6-adduct formed through conjugation of 5-oxoETE with glutathione
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FOG9

Item No. 34265

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-6Z,9S-(S-glutathionyl)-11Z,14Z-eicosatrienoic acid
Synonyms
  • 5-OxoETE-glutathione
Molecular Formula
C30H47N3O9S
Formula Weight
625.8
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 100 µg/ml
λmax
226, 276 nm
SMILES
CCCCC/C=C\C/C=C\CC(C/C=C\C(=O)CCCC(=O)O)SCC(N)(C(=O)NCC(=O)O)N1C(=O)CCC1C(=O)O
InChi Code
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-15-23(16-11-13-22(34)14-12-17-27(36)37)43-21-25(29(40)32-20-28(38)39)33-26(35)19-18-24(31)30(41)42/h6-7,9-11,13,23-25H,2-5,8,12,14-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,13-11-
InChi Key
HUKLMIHNCYZKON-OWJNGHGZSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $152

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    50 µg

    $288

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    100 µg

    $541

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    Product Description

    FOG9 is formed through the conjugation of 5-oxoETE with glutathione in a 1,6 Michael addition at C-9. The biological activity of FOG9 has not been determined. However, FOG7, a 1,4-adduct formed within murine peritoneal macrophages, was found to be highly potent in stimulating eosinophil and neutrophil chemotaxis.1 FOG7 was also capable of initiating actin polymerization without elevating intracellular free calcium ion concentration within either the eosinophil neutrophils or PMNL.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bowers, R.C., Hevko, J., Henson, P.M., et al. A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. The Journal of Biological Chemisty 275, 29931-29934 (2000).