A fluorescent copper complex with anticancer activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Complex 3

Item No. 34282

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tribromobis[μ-[methyl N-[di(2-pyridinyl-κN)methylene]carbonodithiohydrazonato-κN,κS′]]tri-copper
CAS Number
2480150-28-3
Molecular Formula
C26H22Br3Cu3N8S4
Formula Weight
1005.1
Purity
≥90%
Emission
535 nm
Excitation
455-495 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
[Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81
InChi Code
InChI=1S/2C13H12N4S2.3BrH.3Cu/c2*1-19-13(18)17-16-12(10-6-2-4-8-14-10)11-7-3-5-9-15-11;;;;;;/h2*2-9H,1H3,(H,17,18);3*1H;;;/q;;;;;+1;2*+2/p-5
InChi Key
ICCMZVFKEUFYKQ-UHFFFAOYSA-I
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $178

    Add

    10 mg

    $283

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity.1 It localizes to mitochondria and displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells (IC50s = 0.74, 0.41, 0.62, and 2.06 µM, respectively). It induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells, effects that can be reduced by the ferroptosis inhibitor liproxstatin-1 (Item No. 17730). Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in the same cells. In vivo, complex 3 (1.5 and 3 mg/kg) reduces tumor volume and intratumor apoptosis in an AsPC-1 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, Y., Chen, M., Li, S., et al. Dithiocarbazate-copper complexes for bioimaging and treatment of pancreatic cancer. J. Med. Chem. 64(9), 5485-5499 (2021).