An ULK1 activator
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BL 918

Item No. 34303

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-benzeneacetamide
CAS Number
2101517-69-3
Molecular Formula
C23H15F8N3OS
Formula Weight
533.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
251 nm
SMILES
FC(C=C(C=C1)F)=C1NC([C@@H](C2=CC=CC=C2)NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)=O
InChi Code
InChI=1S/C23H15F8N3OS/c24-15-6-7-18(17(25)11-15)33-20(35)19(12-4-2-1-3-5-12)34-21(36)32-16-9-13(22(26,27)28)8-14(10-16)23(29,30)31/h1-11,19H,(H,33,35)(H2,32,34,36)/t19-/m1/s1
InChi Key
BDBWQANRZRCMMD-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

    $231

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    10 mg

    $382

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    25 mg

    $700

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    Product Description

    BL 918 is an activator of unc-51-like autophagy activating kinase 1 (ULK1).1 It activates ULK1 with an EC50 value of 24.14 nM in an ADP-based kinase assay. BL 918 (5 µM) increases the levels of ULK1 phosphorylated at serine 317 (Ser317) or Ser555, reduces the level of ULK1 phosphorylated at Ser757, and induces autophagy in SH-SY5Y cells. It reduces motor dysfunction and increases the number of dopaminergic neurons in the striatum in a mouse model of Parkinson’s disease induced by MPTP when administered at doses of 40 and 80 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ouyang, L., Zhang, L., Zhang, S., et al. Small-molecule activator of UNC-51-like kinase 1 (ULK1) that induces cytoprotective autophagy for Parkinson’s disease treatment. J. Med. Chem. 61(7), 2776-2792 (2018).