An allosteric activator of GCase
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LTI-291

Item No. 34305

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS Number
1919820-28-2
Molecular Formula
C20H30N4O2
Formula Weight
358.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
224, 238 nm
SMILES
CCCCCO[C@@H](CC1)CC[C@H]1NC(C2=C(N=C(C)C=C3C)N3N=C2)=O
InChi Code
InChI=1S/C20H30N4O2/c1-4-5-6-11-26-17-9-7-16(8-10-17)23-20(25)18-13-21-24-15(3)12-14(2)22-19(18)24/h12-13,16-17H,4-11H2,1-3H3,(H,23,25)/t16-,17-
InChi Key
HZILSILAELSWKN-QAQDUYKDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $409

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    50 mg

    $654

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    Product Description

    LTI-291 is a CNS-penetrant allosteric activator of glucocerebrosidase (GCase).1 It increases the activity of wild-type human GCase by 25 and 130% when used at concentrations of 0.1 and 1 µM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. den Heijer, J.M., Kruithof, A.C., van Amerongen, G., et al. A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator. Br. J. Clin. Pharmac. 1-13 (2021).