An LC3B-mutant huntingtin linker
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LC3-mHTT-IN-AN1

Item No. 34306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
CAS Number
486443-73-6
Molecular Formula
C15H9Br2NO3
Formula Weight
411.0
Purity
≥95% (mixture of cis and trans isomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
260, 372 nm
SMILES
O=C1NC2=CC=C(C=C2C1=CC3=CC(Br)=C(C(O)=C3)O)Br
InChi Code
InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
InChi Key
GPKLWRHHVIBYEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

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    10 mg

    $176

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    25 mg

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    Product Description

    LC3-mHTT-IN-AN1 is a linker molecule that interacts with the autophagosome protein microtubule-associated protein 1 light chain 3β (LC3B) and mutant huntingtin (Hdh).1 It decreases HdhQ7/Q140, but not wild-type huntingtin, levels in primary mouse cortical neurons when used at a concentration of 300 nM. LC3-mHTT-IN-AN1 increases survival of Drosophila expressing human HdhQ128.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Z., Wang, C., Wang, Z., et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature 575(7781), 203-209 (2019).