An inhibitor of tau aggregation
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TRx0237 (mesylate)

Item No. 34307

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-diamine, dimethanesulfonate
CAS Number
1236208-20-0
Synonyms
  • Hydromethylthionine
  • Leucomethylene Blue
  • Leukomethylthioninium dihydromesylate
  • LMTM
Molecular Formula
C16H19N3S • 2CH3SO3H
Formula Weight
477.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
237, 264, 656 nm
SMILES
O=S(O)(C)=O.CN(C)C1=CC=C2NC3=CC=C(N(C)C)C=C3SC2=C1.O=S(O)(C)=O
InChi Code
InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)
InChi Key
SPCMQFLNOVTUBM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $105

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    25 mg

    $183

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    50 mg

    $303

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    Product Description

    TRx0237 is an inhibitor of tau aggregation.1 It inhibits tau-tau binding (IC50 = 238 µM) and tau aggregation in 3T6H cells expressing human tau (EC50 = 0.19 µM). TRx0237 (5 and 15 mg/kg) increases hippocampal acetylcholine (ACh) and synaptophysin levels, as well as increases mitochondrial complex IV activity, decreases tau pathology, and reverses deficits in spatial learning in the L1 transgenic mouse model of Alzheimer’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harrington, C.R., Storey, J.M.D., Clunas, S., et al. Cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of Alzheimer disease. The Journal of Biological Chemisty 290(17), 10862-10875 (2015).

    2. Riedel, G., Klein, J., Niewiadomska, G., et al. Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model. Curr. Alzheimer Res. 17(3), 285-296 (2020).