A substrate for AChE and an agonist of α4β2-subunit containing nAChRs
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Acetylthiocholine (iodide)

Item No. 34313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetylthio)-N,N,N-trimethyl-ethanaminium, monoiodide
CAS Number
1866-15-5
Synonyms
  • ASCh
  • ATCh
Molecular Formula
C7H16NOS • I
Formula Weight
289.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C)SCC[N+](C)(C)C.[I-]
InChi Code
InChI=1S/C7H16NOS.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChi Key
NTBLZMAMTZXLBP-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $75

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    10 g

    $134

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    25 g

    $295

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    50 g

    $516

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    Product Description

    Acetylthiocholine is a substrate for acetylcholinesterase (AChE) and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs).1,2 It binds to α4β2 subunit-containing nAChRs in SH-EP1 cells (IC50 = 7.1 µM for the human receptor) and induces rubidium efflux in an agonist-induced rubidium efflux assay (EC50 = 100 µM).2 Acetylthiocholine has been used as part of a thiocholine sensor for the detection of pesticides in complex sample types, such as soil, groundwater, and spinach.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, L., Tian, X., Li, Y., et al. Broad-spectrum pesticide screening by multiple cholinesterases and thiocholine sensors assembled high-throughput optical array system. J. Hazard. Mater. 402, 123830 (2021).

    2. Eaton, J.B., Peng, J.-H., Schroeder, K.M., et al. Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Mol. Pharmacol. 64(6), 1283-1294 (2003).